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<div class="WordSection1">
<p class="MsoNormal">Dear Equals,<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><i>(German version below)<o:p></o:p></i></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">I am Dr Nidaa Mikail, MD, from the University Hospital Zurich (USZ), and I am contacting you regarding a study we are conducting in collaboration with the University of Zurich, entitled “<b><i>Sex-differences in heart-brain crosstalk –
Role of psychosocial stress</i></b>”.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Prof. Dr. Dr. Cathérine Gebhard is the principal investigator of this project, which has been approved by the Swiss Association of Research Ethics Committees (<i>BASEC 2020-02922</i>).
<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Our study aims to explain the differences between women and men in the development of heart attacks. Indeed, despite major diagnostic and therapeutic advances achieved in the last decades, women seem to suffer a heavier burden than men
in terms of heart diseases.<o:p></o:p></p>
<p class="MsoNormal">Recent results point to the role of stress in the development of heart attacks, in both women and men. Our hypothesis is that women could in fact be even more sensitive to stress than men are, and therefore suffer more often from a heart
attack. <o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">To investigate this hypothesis, we are conducting a study in
<b>healthy women and men, aged 50-70 year-old</b>. This study takes place at the <b>
Department for Nuclear Medicine, University Hospital Zurich – Wagistrasse 14, 8952 Schlieren</b>.
<o:p></o:p></p>
<p class="MsoNormal">In case of participation, the course of the study involves a preliminary talk, answering questionnaires, performing imaging tests of the brain and heart in a positron emission tomography/magnetic resonance imager, and undergoing mainly
blood and saliva sampling. This study involves spending a full morning (approximately 5 hours) in the Department of Nuclear Medicine. In compensation, each participant will receive
<b>250 CHF</b>.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><span lang="DE-CH"><a href="https://www.usz.ch/studie/einfluss-des-geschlechts-auf-das-zusammenspiel-von-herz-und-gehirn/">Einfluss des Geschlechts auf das Zusammenspiel von Herz und Gehirn – Universitätsspital Zürich (usz.ch)</a></span><span lang="DE-CH"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH"><o:p> </o:p></span></p>
<p class="MsoNormal">We thought some of you or could be interested in participating in our project.
<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Would you wish additional information, we remain at your entire disposal. We can be reached via email
<a href="herzforschung@usz.ch%20">herzforschung@usz.ch</a> or via phone <b>+41 44 255 2928</b>.<o:p></o:p></p>
<p class="MsoNormal">You can also find more information about our group by visiting our webpage
<a href="www.gebhardlab.com">www.gebhardlab.com</a>.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Yours sincerely,<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><b><span lang="DE-CH" style="font-size:9.0pt;color:#404040">Dr. Nidaa Mikail<o:p></o:p></span></b></p>
<p class="MsoNormal"><b><i><o:p> </o:p></i></b></p>
<div style="mso-element:para-border-div;border:none;border-bottom:solid windowtext 1.5pt;padding:0in 0in 1.0pt 0in">
<p class="MsoNormal" style="border:none;padding:0in"><o:p> </o:p></p>
</div>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><span lang="DE-CH">Liebe Equals,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH">Ich bin Dr. med. Nidaa Mikail vom Universitätsspital Zürich (USZ) und wende mich an Sie bezüglich einer Studie, die wir in Zusammenarbeit mit der Universität Zürich unter dem Titel "</span><span lang="DE-CH">
</span><b><i><span lang="DE-CH">Geschlechtsunterschiede im Herz-Hirn-Crosstalk - Rolle von psychischem Stress</span></i></b><span lang="DE-CH">" durchführen.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH">Prof. Dr. Dr. Cathérine Gebhard ist die Hauptforscherin dieses Projekts, das von der Schweizerischen Vereinigung der Forschungsethikkommissionen (BASEC 2020-02922) genehmigt wurde.
<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH">Ziel unserer Studie ist es, die Unterschiede zwischen Frauen und Männern bei der Entstehung von Herzinfarkten zu erklären. Trotz großer diagnostischer und therapeutischer Fortschritte in den letzten Jahrzehnten scheinen
Frauen in Bezug auf Herzkrankheiten stärker belastet zu sein als Männer.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH">Jüngste Ergebnisse weisen auf die Rolle von Stress bei der Entstehung von Herzinfarkten hin, und zwar sowohl bei Frauen als auch bei Männern. Unsere Hypothese ist, dass Frauen sogar noch stressempfindlicher sein könnten
als Männer und deshalb häufiger einen Herzinfarkt erleiden. <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH">Um diese Hypothese zu untersuchen, führen wir eine Studie an
<b>gesunden Frauen und Männern im Alter von 50-70 Jahren</b> durch. Diese Studie findet an der
<b>Klinik für Nuklearmedizin des Universitätsspitals Zürich - Wagistrasse 14, 8952 Schlieren</b> statt.
<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH">Im Falle einer Teilnahme umfasst der Ablauf der Studie ein Vorgespräch, die Beantwortung von Fragebögen, die Durchführung von bildgebenden Untersuchungen des Gehirns und des Herzens in einem Positronen-Emissions-Tomographen/Magnetresonanztomographen
sowie vor allem die Entnahme von Blut und Speichel. Im Rahmen dieser Studie verbringen die Teilnehmer einen ganzen Vormittag (etwa 5 Stunden) in der Abteilung für Nuklearmedizin. Als Entschädigung erhält jeder Teilnehmer
<b>250 CHF</b>.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH"><a href="https://www.usz.ch/studie/einfluss-des-geschlechts-auf-das-zusammenspiel-von-herz-und-gehirn/">Einfluss des Geschlechts auf das Zusammenspiel von Herz und Gehirn – Universitätsspital Zürich (usz.ch)</a></span><span lang="DE-CH"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH">Wir dachten uns, dass der eine oder andere von Ihnen an einer Teilnahme an unserem Projekt interessiert sein könnte.
<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH">Sollten Sie weitere Informationen wünschen, stehen wir Ihnen gerne zur Verfügung. Sie können uns per E-Mail
<a href="herzforschung@usz.ch%20">herzforschung@usz.ch</a> oder per Telefon <b>+41 44 255 2928</b> erreichen.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH">Weitere Informationen über unsere Gruppe finden Sie auch auf unserer Webseite
<a href="www.gebhardlab.com">www.gebhardlab.com</a>.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH">Liebe Grüsse,<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span lang="DE-CH" style="font-size:9.0pt;color:#404040">Dr. Nidaa Mikail<o:p></o:p></span></b></p>
<p class="MsoNormal"><span lang="DE-CH" style="font-size:9.0pt;color:#404040">Facharzt für Nuklearmedizin</span><span lang="DE-CH" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH" style="font-size:1.0pt;color:#004A98"> </span><span lang="DE-CH" style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black"><img border="0" width="96" height="96" style="width:1.0in;height:1.0in" id="Picture_x0020_2" src="cid:image003.png@01D7CB22.0DEFB9A0"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:1.0pt;color:#004A98"> </span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black"><o:p></o:p></span></p>
<table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0" style="border-collapse:collapse">
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<p class="MsoNormal"><span style="font-size:9.0pt;color:#404040"> University Hospital Zurich</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;color:#404040"> Department of Nuclear Medicine</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;color:#404040"> Cardiovascular Gender Medicine, Prof. Dr. Dr. Cathérine Gebhard</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;color:#404040"> Rämistrasse 100, CH-8091 Zurich</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;color:#404040"> 0041 (0) 44 255 2928</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:1.0pt;color:#004A98"> </span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.0pt;color:#404040"> University of Zurich</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;color:#404040"> Center for Molecular Cardiology</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;color:#404040"> Cardiovascular Gender Medicine, Prof. Dr. Dr. Cathérine Gebhard</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;color:#404040"> Wagistrasse 12, CH-8952, Schlieren</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;color:#404040"> 0041 (0) 44 635 6470</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
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<p class="MsoNormal"><span style="font-size:9.0pt;color:#004A98"> </span><span style="font-size:11.0pt"><a href="http://www.gebhardlab.com/" target="_blank"><span style="font-size:9.0pt;color:#0563C1">www.gebhardlab.com</span></a></span><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="DE-CH"><o:p> </o:p></span></p>
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